Cardiac Electrophysiology Web Lab

Quick start links

What is Functional Curation?

Modellers have adopted XML-based markup languages to describe mathematical models over the past decade. This is great, as it means that models can be defined unambiguously, and shared easily, in a machine-readable format.

We have been trying to do the same thing with 'protocols' - to define what you have to do to replicate/simulate an experiment, and analyse the results. We can then curate models according to their functional behaviour under a range of experimental scenarios.

For the first time, we can thus easily compare how different models react to the same protocol, or compare how a model behaves under different protocols.

Read more...

What is this website?

This is our prototype system for cardiac electrophysiology. It brings together models encoded using CellML and virtual experiment protocols encoded in our own language, using standardised tags to generate interfaces between them, doing all the necessary units conversions. The stored results of these experiments can be viewed and compared.

Comparison examples:

If you wish to analyse your own models or create new protocols, you will need to register for an account and have it approved.

Chaste - Functional Curation Schematic
A schematic of the way we organise model and protocol descriptions. This website provides an interface to a Model/Protocol Simulator, storing and displaying the results. (Adapted from Cooper, Vik and Waltemath 2014, figure 1.)

Have a look at the main experiment database to get started, or read more about the system.